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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69250
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wnt5a
Name: Wnt family member 5A
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wnt5aincreases expressionISOWNT5A (Homo sapiens)6480464CTDFulvestrant results in increased expression of WNT5A mRNAPMID:31646340
Wnt5amultiple interactionsISOWNT5A (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in decreased methylation of WNT5A gene; arsenite inhibits the reaction [Fulvestrant results in increased expression of WNT5A mRNA]; Cadmium inhibits the reaction [Fulvestrant results in increased expression of WNT5A mRNA]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of WNT5A mRNA]PMID:31601247 PMID:31646340
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