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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69250
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wnt5a
Name: Wnt family member 5A
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wnt5aincreases expressionEXP 6480464CTDEstradiol results in increased expression of WNT5A mRNAPMID:31119341
Wnt5amultiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of WNT5A mRNAPMID:26496021
Wnt5adecreases expressionISOWNT5A (Homo sapiens)6480464CTDEstradiol results in decreased expression of WNT5A mRNAPMID:31614463 PMID:31646340
Wnt5aincreases expressionISOWNT5A (Homo sapiens)6480464CTDEstradiol results in increased expression of WNT5A mRNAPMID:19619570
Wnt5aincreases expressionISOWnt5a (Mus musculus)6480464CTDEstradiol results in increased expression of WNT5A mRNAPMID:19484750
Wnt5amultiple interactionsISOWNT5A (Homo sapiens)6480464CTD[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of WNT5A mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of WNT5A mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of WNT5A mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of WNT5A mRNA; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of WNT5A mRNA]PMID:19619570 PMID:20660070 PMID:20823114 PMID:30165855 PMID:31646340
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