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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68433
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aqp9
Name: aquaporin 9
Acc ID: CHEBI:17276
Term: phloretin
Definition: A member of the class of dihydrochalcones that is dihydrochalcone substituted by hydroxy groups at positions 4, 2', 4' and 6'.
Chemical ID: MESH:D010693
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp9decreases activityEXP 6480464CTDPhloretin results in decreased activity of AQP9 proteinPMID:21259319 PMID:9733774
Aqp9multiple interactionsEXP 6480464CTDPhloretin inhibits the reaction [AQP9 protein results in increased transport of Water]; Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]PMID:12606488 PMID:9733774
Aqp9multiple interactionsISOAQP9 (Homo sapiens)6480464CTDPhloretin inhibits the reaction [AQP9 protein results in increased uptake of Lactic Acid]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Selenic Acid analog]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid]PMID:28798983
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