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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cldn3
Name: claudin 3
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cldn3multiple interactionsISOCLDN3 (Homo sapiens)6480464CTD[decitabine co-treated with trichostatin A] inhibits the reaction [MBD2 protein binds to CLDN3 promoter]; [decitabine co-treated with trichostatin A] promotes the reaction [SP1 protein binds to CLDN3 promoter]; [decitabine co-treated with trichostatin A] promotes the reaction [SP3 protein binds to CLDN3 promoter]; trichostatin A inhibits the reaction [Nickel affects the expression of CLDN3 mRNA]; trichostatin A promotes the reaction [decitabine results in increased expression of CLDN3 mRNA]; trichostatin A promotes the reaction [decitabine results in increased expression of CLDN3 protein]PMID:14575637 PMID:17986852
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