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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68374
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cox4i1
Name: cytochrome c oxidase subunit 4i1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cox4i1decreases expressionISOCOX4I1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of COX4I1 proteinPMID:27318970
Cox4i1increases expressionISOCOX4I1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of COX4I1 mRNAPMID:20458559
Cox4i1multiple interactionsISOCOX4I1 (Homo sapiens)6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Arsenic Trioxide results in decreased expression of COX4I1 protein]; Cyclosporine inhibits the reaction [Arsenic Trioxide results in decreased expression of COX4I1 protein]PMID:27318970
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