GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Slc22a8 | multiple interactions | EXP | | 6480464 | CTD | [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Penicillin G]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Ranitidine] | PMID:10224140 PMID:15319347 PMID:16006492 PMID:35019195 PMID:35114312 | Slc22a8 | decreases activity | ISO | SLC22A8 (Homo sapiens) | 6480464 | CTD | Probenecid results in decreased activity of SLC22A8 protein | PMID:28629854 PMID:29045746 PMID:31364238 PMID:31830554 PMID:32305507 | Slc22a8 | decreases expression | ISO | SLC22A8 (Homo sapiens) | 6480464 | CTD | Probenecid results in decreased expression of SLC22A8 mRNA; Probenecid results in decreased expression of SLC22A8 protein | PMID:23129053 | Slc22a8 | decreases expression | ISO | Slc22a8 (Mus musculus) | 6480464 | CTD | Probenecid results in decreased expression of SLC22A8 mRNA | PMID:26788513 | Slc22a8 | multiple interactions | ISO | SLC22A8 (Homo sapiens) | 6480464 | CTD | Probenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]; Probenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamide)-3,3-dimethylbutanoate metabolite] | PMID:11306713 PMID:16006492 PMID:19643159 PMID:27989701 PMID:28629854 PMID:28890383 PMID:32003934 PMID:32305507 PMID:33236189 | | ||||||||||||||||||||||
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