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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 632286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a8
Name: solute carrier family 22 member 8
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a8decreases expressionEXP 6480464CTDochratoxin A results in decreased expression of SLC22A8 mRNA; ochratoxin A results in decreased expression of SLC22A8 proteinPMID:19538982 PMID:29126803 PMID:30120945
Slc22a8increases expressionEXP 6480464CTDochratoxin A results in increased expression of SLC22A8 mRNA; ochratoxin A results in increased expression of SLC22A8 proteinPMID:19538982 PMID:30120945
Slc22a8increases uptakeEXP 6480464CTDSLC22A8 protein results in increased uptake of ochratoxin APMID:10224140
Slc22a8affects transportISOSLC22A8 (Homo sapiens)6480464CTDSLC22A8 protein affects the transport of ochratoxin APMID:11306713
Slc22a8increases uptakeISOSLC22A8 (Homo sapiens)6480464CTDSLC22A8 protein results in increased uptake of ochratoxin APMID:16098483
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