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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 632286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a8
Name: solute carrier family 22 member 8
Acc ID: CHEBI:4975
Term: famotidine
Definition: A guanidine that has formula C8H15N7O2S3.
Chemical ID: MESH:D015738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a8increases uptakeEXP 6480464CTDSLC22A8 protein results in increased uptake of FamotidinePMID:15319347 PMID:16006492
Slc22a8multiple interactionsEXP 6480464CTDFamotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]PMID:15319347 PMID:16006492
Slc22a8increases uptakeISOSLC22A8 (Homo sapiens)6480464CTDSLC22A8 protein results in increased uptake of FamotidinePMID:15496291 PMID:16006492
Slc22a8multiple interactionsISOSLC22A8 (Homo sapiens)6480464CTDestrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]PMID:15496291 PMID:16006492
Slc22a8multiple interactionsISOSlc22a8 (Mus musculus)6480464CTDFamotidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]PMID:15100168
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