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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 632286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a8
Name: solute carrier family 22 member 8
Acc ID: CHEBI:47426
Term: furosemide
Definition: A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.
Chemical ID: MESH:D005665
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a8multiple interactionsEXP 6480464CTDFurosemide inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]PMID:10224140
Slc22a8decreases activityISOSlc22a8 (Mus musculus)6480464CTDFurosemide results in decreased activity of SLC22A8 proteinPMID:18216144
Slc22a8increases secretionISOSlc22a8 (Mus musculus)6480464CTDSLC22A8 protein results in increased secretion of FurosemidePMID:18216144
Slc22a8multiple interactionsISOSLC22A8 (Homo sapiens)6480464CTDFurosemide inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]PMID:11306713
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