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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 632286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a8
Name: solute carrier family 22 member 8
Acc ID: CHEBI:44185
Term: methotrexate
Definition: A pteridine that has formula C20H22N8O5.
Chemical ID: MESH:D008727
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a8decreases expressionEXP 6480464CTDMethotrexate results in decreased expression of SLC22A8 proteinPMID:16925582
Slc22a8increases uptakeEXP 6480464CTDSLC22A8 protein results in increased uptake of MethotrexatePMID:35019195
Slc22a8multiple interactionsEXP 6480464CTDLeucovorin inhibits the reaction [Methotrexate results in decreased expression of SLC22A8 protein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]; tranilast inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]PMID:16925582 PMID:35019195
Slc22a8affects transportISOSLC22A8 (Homo sapiens)6480464CTDSLC22A8 protein affects the transport of MethotrexatePMID:11306713
Slc22a8increases response to substanceISOSLC22A8 (Homo sapiens)6480464CTDSLC22A8 protein results in increased susceptibility to MethotrexatePMID:27377006
Slc22a8increases uptakeISOSLC22A8 (Homo sapiens)6480464CTDSLC22A8 protein results in increased uptake of MethotrexatePMID:16098483 PMID:27377006 PMID:28890383
Slc22a8multiple interactionsISOSLC22A8 (Homo sapiens)6480464CTDresveratrol inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]; rhein metabolite inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]PMID:27377006 PMID:28890383
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