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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 632286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a8
Name: solute carrier family 22 member 8
Acc ID: CHEBI:3013
Term: bendroflumethiazide
Definition: A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group.
Chemical ID: MESH:D001539
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a8decreases activityISOSlc22a8 (Mus musculus)6480464CTDBendroflumethiazide results in decreased activity of SLC22A8 proteinPMID:18216144
Slc22a8increases secretionISOSlc22a8 (Mus musculus)6480464CTDSLC22A8 protein results in increased secretion of BendroflumethiazidePMID:18216144
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