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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 632286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a8
Name: solute carrier family 22 member 8
Acc ID: CHEBI:18208
Term: benzylpenicillin
Definition: A penicillin in which the substituent at position 6 of the penam ring is a phenylacetamido group.
Chemical ID: MESH:D010400
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a8increases uptakeEXP 6480464CTDSLC22A8 protein results in increased uptake of Penicillin GPMID:35019195
Slc22a8multiple interactionsEXP 6480464CTDPenicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Ranitidine]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Penicillin G]; tranilast inhibits the reaction [SLC22A8 protein results in increased uptake of Penicillin G]PMID:10224140 PMID:15319347 PMID:35019195
Slc22a8increases uptakeISOSLC22A8 (Homo sapiens)6480464CTDSLC22A8 protein results in increased uptake of Penicillin GPMID:17255469 PMID:27377006
Slc22a8multiple interactionsISOSLC22A8 (Homo sapiens)6480464CTDresveratrol inhibits the reaction [SLC22A8 protein results in increased uptake of Penicillin G]PMID:27377006
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