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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631440
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aadac
Name: arylacetamide deacetylase
Acc ID: CHEBI:45304
Term: rifapentine
Definition: A N-iminopiperazine that has formula C47H64N4O12.
Chemical ID: MESH:C018421
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aadacdecreases acetylationISOAADAC (Homo sapiens)6480464CTDAADAC protein results in decreased acetylation of rifapentinePMID:21856291
Aadacmultiple interactionsISOAADAC (Homo sapiens)6480464CTDAADAC mRNA affects the reaction [rifapentine results in increased expression of CYP3A4 mRNA]; bis(4-nitrophenyl)phosphate inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine]; Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine]; Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine]; Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine]; Sodium Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine]PMID:21856291
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