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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631434
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bbc3
Name: Bcl-2 binding component 3
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bbc3increases expressionISOBBC3 (Homo sapiens)6480464CTDFluorouracil results in increased expression of BBC3 mRNA; Fluorouracil results in increased expression of BBC3 proteinPMID:14665630 PMID:15489892 PMID:16481741 PMID:16557594 PMID:22525470
Bbc3increases response to substanceISOBBC3 (Homo sapiens)6480464CTDBBC3 protein results in increased susceptibility to FluorouracilPMID:16481741
Bbc3multiple interactionsISOBBC3 (Homo sapiens)6480464CTD[[Chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with Glyphosate] results in decreased susceptibility to Fluorouracil] which results in decreased expression of BBC3 mRNA; mithramycin A inhibits the reaction [Fluorouracil results in increased expression of BBC3 protein]; TP53 protein affects the reaction [Fluorouracil results in increased expression of BBC3 mRNA]; TP53 protein affects the reaction [Fluorouracil results in increased expression of BBC3 protein]PMID:14665630 PMID:15016801 PMID:15489892 PMID:32800223
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