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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631397
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lat2
Name: linker for activation of T cells family, member 2
Acc ID: CHEBI:67272
Term: perifosine
Definition: A phospholipid consisting of 1,1-dimethylpiperidinium-4-yl hydrogen phosphate in which the hydrogen is replaced by a stearyl (octadecyl) group.
Chemical ID: MESH:C105905
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lat2decreases expressionISOLAT2 (Homo sapiens)6480464CTDperifosine results in decreased expression of LAT2 proteinPMID:23001822
Lat2decreases response to substanceISOLAT2 (Homo sapiens)6480464CTDLAT2 protein results in decreased susceptibility to perifosinePMID:23001822
Lat2multiple interactionsISOLAT2 (Homo sapiens)6480464CTDixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]; LAT2 protein inhibits the reaction [perifosine results in increased cleavage of PARP1 protein]; LAT2 protein inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form]PMID:23001822 PMID:32587277
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