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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631362
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapkapk2
Name: MAPK activated protein kinase 2
Acc ID: CHEBI:16547
Term: coniferyl aldehyde
Definition: A member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Chemical ID: MESH:C075384
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapkapk2multiple interactionsISOMAPKAPK2 (Homo sapiens)6480464CTDMAPKAPK2 mutant form inhibits the reaction [coniferaldehyde affects the localization of and results in increased phosphorylation of NFE2L2 protein]; MAPKAPK2 mutant form inhibits the reaction [coniferaldehyde results in increased expression of HMOX1 protein]PMID:26275128
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