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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631362
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapkapk2
Name: MAPK activated protein kinase 2
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapkapk2increases expressionISOMAPKAPK2 (Homo sapiens)6480464CTDTretinoin results in increased expression of MAPKAPK2 mRNAPMID:17218384 PMID:33167477
Mapkapk2increases phosphorylationISOMAPKAPK2 (Homo sapiens)6480464CTDTretinoin results in increased phosphorylation of MAPKAPK2 proteinPMID:30709899
Mapkapk2multiple interactionsISOMAPKAPK2 (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [Tretinoin results in increased phosphorylation of MAPKAPK2 protein]PMID:30709899
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