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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628895
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aurka
Name: aurora kinase A
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aurkaaffects expressionEXP 6480464CTDbisphenol A affects the expression of AURKA mRNAPMID:32145629
Aurkadecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of AURKA mRNAPMID:25181051 PMID:30816183
Aurkamultiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of AURKA mRNAPMID:36041667
Aurkaaffects expressionISOAURKA (Homo sapiens)6480464CTDbisphenol A affects the expression of AURKA mRNAPMID:35628146
Aurkadecreases expressionISOAURKA (Homo sapiens)6480464CTDbisphenol A results in decreased expression of AURKA mRNAPMID:29275510
Aurkaincreases expressionISOAURKA (Homo sapiens)6480464CTDbisphenol A results in increased expression of AURKA mRNAPMID:16474171 PMID:17268063 PMID:22576693
Aurkaincreases methylationISOAurka (Mus musculus)6480464CTDbisphenol A results in increased methylation of AURKA promoterPMID:27312807
Aurkaincreases phosphorylationISOAURKA (Homo sapiens)6480464CTDbisphenol A results in increased phosphorylation of AURKA proteinPMID:30980863
Aurkamultiple interactionsISOAURKA (Homo sapiens)6480464CTDbisphenol A inhibits the reaction [Doxorubicin results in increased expression of AURKA mRNA]PMID:26320837
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