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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mfn2
Name: mitofusin 2
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mfn2increases response to substanceEXP 6480464CTDMFN2 protein results in increased susceptibility to epigallocatechin gallatePMID:28478070
Mfn2multiple interactionsEXP 6480464CTDepigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 mRNA]; epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein]; KLF4 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 mRNA]]; KLF4 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in decreased expression of MFN2 protein]]; MFN2 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]]; MFN2 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]]PMID:28478070
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