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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628774
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l11
Name: Bcl2-like 11
Acc ID: CHEBI:88249
Term: PD 0325901
Definition: A hydroxamic acid ester that is benzhydroxamic acid (N-hydroxybenzamide) in which the hydroxamic acid group has been converted to the corresponding 2,3-dihydroxypropyl ester and in which the benzene ring has been substituted at position 2 by a (2-fluoro-4-iodophenyl)amino group and at positions 3 and 4 by fluorines (the R enantiomer).
Chemical ID: MESH:C506614
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l11increases expressionISOBCL2L11 (Homo sapiens)6480464CTDmirdametinib results in increased expression of BCL2L11 proteinPMID:24576621 PMID:27634878
Bcl2l11multiple interactionsISOBCL2L11 (Homo sapiens)6480464CTD[mirdametinib co-treated with MK 2206] results in increased expression of BCL2L11 protein; [romidepsin co-treated with mirdametinib co-treated with MK 2206] results in increased expression of BCL2L11 protein; [romidepsin co-treated with mirdametinib] results in increased expression of BCL2L11 protein; KRAS protein affects the reaction [mirdametinib results in increased expression of BCL2L11 protein]; KRAS protein affects the reaction [NVP-BKM120 promotes the reaction [mirdametinib results in increased expression of BCL2L11 protein]]; NVP-BKM120 promotes the reaction [mirdametinib results in increased expression of BCL2L11 protein]PMID:24576621 PMID:27634878
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