GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2l11 | increases response to substance | ISO | Bcl2l11 (Mus musculus) | 6480464 | CTD | BCL2L11 protein results in increased susceptibility to ABT-737 | PMID:20038611 | Bcl2l11 | multiple interactions | ISO | BCL2L11 (Homo sapiens) | 6480464 | CTD | [ABT-737 inhibits the reaction [BCL2L11 protein binds to BCL2 protein]] promotes the reaction [BCL2L11 protein results in increased activity of BAX protein]; [BCL2L11 protein binds to BCL2 protein] which affects the susceptibility to ABT-737; [MCL1 protein results in decreased activity of BCL2L11 protein] which results in decreased susceptibility to ABT-737; ABT-737 inhibits the reaction [BCL2L11 protein binds to BCL2 protein] | PMID:17097560 PMID:17200714 PMID:23341456 | |
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