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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628763
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aqp11
Name: aquaporin 11
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp11increases expressionEXP 6480464CTDCisplatin results in increased expression of AQP11 mRNAPMID:22023808
Aqp11decreases expressionISOAQP11 (Homo sapiens)6480464CTDCisplatin results in decreased expression of AQP11 mRNAPMID:27594783
Aqp11increases expressionISOAQP11 (Homo sapiens)6480464CTDCisplatin results in increased expression of AQP11 mRNAPMID:27392435
Aqp11multiple interactionsISOAQP11 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of AQP11 mRNAPMID:27392435
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