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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aip
Name: aryl-hydrocarbon receptor-interacting protein
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aipdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of AIP mRNAPMID:21215274
Aipincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of AIP mRNAPMID:33387578
Aipmultiple interactionsEXP 6480464CTDTetrachlorodibenzodioxin inhibits the reaction [arsenite promotes the reaction [AIP protein binds to AHR protein]]PMID:22159698
Aipaffects expressionISOAip (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of AIP mRNAPMID:21570461 PMID:24680724
Aipincreases expressionISOAIP (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of AIP mRNAPMID:21998131
Aipmultiple interactionsISOAip (Mus musculus)6480464CTDAIP protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; kaempferol inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]PMID:20450880 PMID:9083006
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