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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621676
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2affects expressionISOActa2 (Mus musculus)6480464CTDAcetaminophen affects the expression of ACTA2 mRNAPMID:17562736
Acta2increases expressionISOACTA2 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of ACTA2 mRNAPMID:22230336
Acta2increases expressionISOActa2 (Mus musculus)6480464CTDAcetaminophen results in increased expression of ACTA2 mRNA; Acetaminophen results in increased expression of ACTA2 proteinPMID:18544908 PMID:28286204 PMID:29246445 PMID:29355602
Acta2multiple interactionsISOActa2 (Mus musculus)6480464CTDandrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 mRNA]; andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]; EGR1 protein affects the reaction [Acetaminophen results in increased expression of ACTA2 mRNA]; EGR1 protein affects the reaction [Acetaminophen results in increased expression of ACTA2 protein]; NFE2L2 gene mutant form inhibits the reaction [andrographolide inhibits the reaction [Acetaminophen results in increased expression of ACTA2 protein]]; NFE2L2 gene mutant form promotes the reaction [Acetaminophen results in increased expression of ACTA2 mRNA]; NFE2L2 gene mutant form promotes the reaction [Acetaminophen results in increased expression of ACTA2 protein]; PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of ACTA2 mRNA]PMID:28286204 PMID:29246445 PMID:29355602
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