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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621676
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:34306
Term: 20-HETE
Definition: A HETE that consists of arachidonic acid bearing a hydroxy substituent at position 20.
Chemical ID: MESH:C055987
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2increases expressionISOACTA2 (Homo sapiens)6480464CTD20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased expression of ACTA2 mRNA; 20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased expression of ACTA2 proteinPMID:36368619
Acta2multiple interactionsISOACTA2 (Homo sapiens)6480464CTD20-hydroxyeicosa-5(Z),14(Z)-dienoic acid promotes the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased expression of ACTA2 mRNA]; 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid promotes the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased expression of ACTA2 protein]; 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased expression of ACTA2 mRNA]; 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased expression of ACTA2 protein]PMID:36368619
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