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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621676
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:15647
Term: leukotriene B4
Definition: A leukotriene composed of (6Z,8E,10E,14Z)-icosatetraenoic acid having (5S)- and (12R)-hydroxy substituents. It is a lipid mediator of inflammation that is generated from arachidonic acid via the 5-lipoxygenase pathway.
Chemical ID: MESH:D007975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2increases expressionISOACTA2 (Homo sapiens)6480464CTDLeukotriene B4 results in increased expression of ACTA2 proteinPMID:27697457
Acta2increases expressionISOActa2 (Mus musculus)6480464CTDLeukotriene B4 results in increased expression of ACTA2 mRNAPMID:30818366
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