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GENE - TERM ANNOTATION REPORT

RGD ID: 621455
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Twist1
Name: twist family bHLH transcription factor 1
Acc ID: DOID:0050827
Term: rheumatic heart disease
Definition: A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Rheumatic_heart_disease "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Twist1 IEP 155882558RGDmRNA, protein:increases expression:mitral valve, heart (rat) 
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