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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptch1
Name: patched 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptch1affects localizationISOPTCH1 (Homo sapiens)6480464CTDFluorouracil affects the localization of PTCH1 proteinPMID:18776995
Ptch1decreases expressionISOPTCH1 (Homo sapiens)6480464CTDFluorouracil results in decreased expression of PTCH1 mRNA; Fluorouracil results in decreased expression of PTCH1 proteinPMID:18776995 PMID:25190613
Ptch1multiple interactionsISOPTCH1 (Homo sapiens)6480464CTD[Fluorouracil co-treated with irinotecan] results in increased expression of PTCH1 mRNA; GLI1 protein inhibits the reaction [Fluorouracil affects the localization of PTCH1 protein]PMID:16391804 PMID:18776995
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