GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mmp9 | increases expression | ISO | MMP9 (Homo sapiens) | 6480464 | CTD | Irinotecan metabolite results in increased expression of MMP9 mRNA; Irinotecan results in increased expression of MMP9 mRNA | PMID:15956246 | Mmp9 | multiple interactions | ISO | MMP9 (Homo sapiens) | 6480464 | CTD | [Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased expression of MMP9 protein; Irinotecan results in decreased secretion of and results in decreased activity of and affects the expression of MMP9 protein | PMID:36191607 | |
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