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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9decreases activityEXP 6480464CTDresveratrol results in decreased activity of MMP9 proteinPMID:21962734
Mmp9decreases expressionEXP 6480464CTDresveratrol results in decreased expression of MMP9 mRNA; resveratrol results in decreased expression of MMP9 proteinPMID:19228061 PMID:22552115 PMID:23075401 PMID:25462211
Mmp9multiple interactionsEXP 6480464CTD[Dimethyl Sulfoxide co-treated with Resveratrol] inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; [raspberry ketone co-treated with Resveratrol] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein]; [Resveratrol co-treated with raspberry ketone] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 mRNA]; Leuprolide inhibits the reaction [Resveratrol results in decreased expression of MMP9 protein]; Resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP9 protein]; Resveratrol inhibits the reaction [Leuprolide results in decreased expression of MMP9 protein]; Resveratrol inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of MMP9 protein]; Resveratrol inhibits the reaction [manganese chloride results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of MMP9 mRNA]PMID:12208745 PMID:15734790 PMID:22191573 PMID:23811825 PMID:25462211 PMID:26497626 PMID:37009719
Mmp9affects expressionISOMMP9 (Homo sapiens)6480464CTDresveratrol affects the expression of MMP9 proteinPMID:17007354
Mmp9decreases activityISOMMP9 (Homo sapiens)6480464CTDresveratrol results in decreased activity of MMP9 proteinPMID:15688415 PMID:17935668
Mmp9decreases expressionISOMMP9 (Homo sapiens)6480464CTDResveratrol results in decreased expression of MMP9; Resveratrol results in decreased expression of MMP9 mRNA; Resveratrol results in decreased expression of MMP9 proteinPMID:14627504 PMID:16490592 PMID:17935668 PMID:18334147 PMID:18674879 PMID:21209944 PMID:21238464 PMID:23992306 PMID:24841706 PMID:26310874 PMID:26911335 PMID:26959057 PMID:27064016
Mmp9decreases expressionISOMmp9 (Mus musculus)6480464CTDresveratrol results in decreased expression of MMP9 mRNAPMID:16304905 PMID:16321402
Mmp9decreases secretionISOMMP9 (Homo sapiens)6480464CTDresveratrol results in decreased secretion of MMP9 proteinPMID:18674879
Mmp9increases secretionISOMMP9 (Homo sapiens)6480464CTDresveratrol results in increased secretion of MMP9 proteinPMID:22314268
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in increased expression of and results in increased activity of MMP9 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Resveratrol affects the expression of MMP9 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; [Glucose co-treated with Resveratrol] results in decreased expression of MMP9 mRNA; [Resveratrol results in decreased expression of [RELA co-treated with FOS]] which results in decreased expression of MMP9; [Resveratrol results in increased expression of SIRT1] which results in decreased expression of MMP9; [SU 1498 results in decreased activity of KDR protein] inhibits the reaction [Resveratrol results in increased secretion of MMP9 protein]; ATG5 protein affects the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; BECN1 protein affects the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Gefitinib promotes the reaction [Resveratrol inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]]; Gefitinib promotes the reaction [Resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of MMP9 mRNA]]; Niacinamide inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; pyrazolanthrone inhibits the reaction [Resveratrol results in decreased expression of MMP9]; Resveratrol inhibits the reaction [2,2'-Dipyridyl results in increased activity of MMP9 protein]; Resveratrol inhibits the reaction [7-ketocholesterol results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein]; Resveratrol inhibits the reaction [HMOX1 protein results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [Niacinamide results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [NRG1 protein alternative form results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [Temozolomide results in decreased expression of MMP9 protein]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of MMP9 protein]; Resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Resveratrol inhibits the reaction [TGFB1 protein results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [TGFB1 protein results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; Resveratrol inhibits the reaction [TNF protein results in increased expression of and results in increased activity of MMP9 protein]; Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Resveratrol promotes the reaction [Gefitinib inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]]; Resveratrol promotes the reaction [Gefitinib inhibits the reaction [lysophosphatidic acid results in increased expression of MMP9 mRNA]]; Resveratrol results in decreased expression of and results in decreased activity of MMP9 protein; Resveratrol results in increased expression of and results in increased activity of MMP9 protein; SB 203580 promotes the reaction [Resveratrol results in decreased expression of MMP9]; SB 203580 promotes the reaction [Resveratrol results in increased expression of and results in increased activity of MMP9 protein]; SIRT1 protein affects the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; SIRT1 protein affects the reaction [Resveratrol results in decreased expression of MMP9 protein]PMID:14627504 PMID:16317118 PMID:17007354 PMID:17049120 PMID:17055343 PMID:17651959 PMID:18674879 PMID:19371443 PMID:20461740 PMID:21238464 PMID:22314268 PMID:22523472 PMID:22530672 PMID:22595400 PMID:22696189 PMID:23127547 PMID:23229870 PMID:23257246 PMID:23992306 PMID:24064760 PMID:24145604 PMID:24841706 PMID:24895526 PMID:24962570 PMID:25200491 PMID:25884904 PMID:26497626 PMID:26959057
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTD[Resveratrol co-treated with Glucose] results in decreased activity of MMP9 protein; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [Aluminum Chloride results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [Aluminum Chloride results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [Calcium Chloride results in increased activity of MMP9 protein]; Resveratrol inhibits the reaction [Croton Oil results in increased expression of MMP9 protein]; Resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased secretion of MMP9 protein]; Resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MMP9 mRNA]; Resveratrol inhibits the reaction [Sodium Fluoride results in decreased expression of MMP9 protein]; Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; Resveratrol results in decreased expression of and results in decreased activity of MMP9 protein; SIRT1 mutant form inhibits the reaction [Resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MMP9 protein]]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]PMID:14515793 PMID:16321402 PMID:21530968 PMID:22069489 PMID:23625030 PMID:24659233 PMID:24682241 PMID:35156769 PMID:36063856
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