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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:9927
Term: valsartan
Definition: A monocarboxylic acid amide consisting of L-valine in which the amino hydrogens have been replaced by a pentanoyl and a [2'-(1H-tetrazol-5-yl)biphenyl]-4-yl]methyl group. It exhibits antihypertensive activity.
Chemical ID: MESH:C081489
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9decreases expressionEXP 6480464CTDValsartan results in decreased expression of MMP9 mRNA; Valsartan results in decreased expression of MMP9 proteinPMID:21051829
Mmp9multiple interactionsEXP 6480464CTD[Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 proteinPMID:21051829
Mmp9decreases activityISOMmp9 (Mus musculus)6480464CTDValsartan results in decreased activity of MMP9 proteinPMID:35235860
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDFluorouracil promotes the reaction [Valsartan results in decreased activity of MMP9 protein]PMID:35235860
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