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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:9150
Term: simvastatin
Definition: A member of the class of hexahydronaphthalenes that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
Chemical ID: MESH:D019821
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionEXP 6480464CTDSimvastatin results in decreased expression of MMP2 mRNAPMID:18309148
Mmp2increases activityEXP 6480464CTDSimvastatin results in increased activity of MMP2 proteinPMID:23831763
Mmp2multiple interactionsEXP 6480464CTDSimvastatin inhibits the reaction [Monocrotaline results in increased expression of MMP2 mRNA]; Simvastatin results in decreased expression of and results in decreased activity of MMP2 proteinPMID:18309148 PMID:22022327
Mmp2decreases activityISOMMP2 (Homo sapiens)6480464CTDSimvastatin results in decreased activity of MMP2 proteinPMID:17158816
Mmp2decreases activityISOMmp2 (Mus musculus)6480464CTDSimvastatin results in decreased activity of MMP2 proteinPMID:17169357
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDSimvastatin results in decreased expression of MMP2 proteinPMID:17038636 PMID:19360310
Mmp2increases activityISOMMP2 (Homo sapiens)6480464CTDSimvastatin results in increased activity of MMP2 proteinPMID:15210533
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDSimvastatin affects the reaction [IL1B protein results in increased activity of MMP2 protein]; Simvastatin inhibits the reaction [IL1B protein results in increased expression of MMP2 mRNA]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]PMID:17038636 PMID:31260663
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