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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases activityEXP 6480464CTDIndomethacin results in increased activity of MMP2 proteinPMID:10878458
Mmp2multiple interactionsEXP 6480464CTDIndomethacin results in decreased expression of and results in decreased secretion of and results in decreased activity of MMP2 protein; Indomethacin results in decreased expression of and results in decreased secretion of MMP2 protein; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of and results in decreased activity of MMP2 protein]; Melatonin inhibits the reaction [Indomethacin results in decreased expression of and results in decreased secretion of MMP2 protein]PMID:16150113 PMID:16934674
Mmp2decreases activityISOMmp2 (Mus musculus)6480464CTDIndomethacin results in decreased activity of MMP2 proteinPMID:16537180
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDIndomethacin results in decreased expression of and results in decreased activity of MMP2 proteinPMID:11719597
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTD[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [Indomethacin co-treated with Medroxyprogesterone Acetate] results in decreased activity of MMP2 proteinPMID:16537180 PMID:33091441
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