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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:4775
Term: ellagic acid
Definition: An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates.
Chemical ID: MESH:D004610
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases activityISOMMP2 (Homo sapiens)6480464CTDEllagic Acid results in decreased activity of MMP2 proteinPMID:35179410
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDEllagic Acid results in decreased expression of MMP2 mRNAPMID:35179410
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDEllagic Acid results in decreased activity of and results in decreased secretion of MMP2 protein; zinc chloride inhibits the reaction [Ellagic Acid results in decreased activity of and results in decreased secretion of MMP2 protein]PMID:21573219
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