Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Hydrogen Sulfide results in increased expression of MMP2 mRNA]; Dexamethasone inhibits the reaction [Hydrogen Sulfide results in increased expression of MMP2 protein]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Hydrogen Sulfide results in increased expression of MMP2 mRNA]]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [Hydrogen Sulfide results in increased expression of MMP2 protein]]PMID:24722316
Mmp2affects expressionISOMmp2 (Mus musculus)6480464CTDDexamethasone affects the expression of MMP2 mRNAPMID:21277400
Mmp2decreases activityISOMmp2 (Mus musculus)6480464CTDDexamethasone results in decreased activity of MMP2 proteinPMID:15990687
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of MMP2 mRNA; Dexamethasone results in decreased expression of MMP2 proteinPMID:32619553
Mmp2increases secretionISOMMP2 (Homo sapiens)6480464CTDDexamethasone results in increased secretion of MMP2 proteinPMID:32294208
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDDexamethasone affects the reaction [IL1B protein affects the expression of MMP2 mRNA]; Dexamethasone inhibits the reaction [sodium bisulfide results in increased expression of MMP2 mRNA]; Dexamethasone inhibits the reaction [sodium bisulfide results in increased expression of MMP2 protein]; Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [sodium bisulfide results in increased expression of MMP2 mRNA]]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [sodium bisulfide results in increased expression of MMP2 protein]]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of MMP2 mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of MMP2 protein]PMID:10455257 PMID:24722316 PMID:32619553 PMID:35405071
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTD[BMP7 protein co-treated with INS1 protein co-treated with Triiodothyronine co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Indomethacin co-treated with Nicotine] affects the expression of MMP2 mRNA; [IL10 protein co-treated with Dexamethasone] inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 protein]PMID:33091441 PMID:37177863
Go Back to source page   Continue to Ontology report