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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:3312
Term: calcium dichloride
Definition: A calcium salt that has formula CaCl2.
Chemical ID: MESH:D002122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases expressionEXP 6480464CTDCalcium Chloride results in increased expression of MMP2 mRNA; Calcium Chloride results in increased expression of MMP2 proteinPMID:20621845
Mmp2increases activityISOMmp2 (Mus musculus)6480464CTDCalcium Chloride results in increased activity of MMP2 proteinPMID:16159824 PMID:21530968 PMID:24337353
Mmp2increases expressionISOMmp2 (Mus musculus)6480464CTDCalcium Chloride results in increased expression of MMP2 mRNA; Calcium Chloride results in increased expression of MMP2 proteinPMID:22728078
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDCalcium Chloride inhibits the reaction [2,3-dihydroxybenzoic acid results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [Deferoxamine results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [Ferrichrome results in decreased activity of MMP2 protein]; Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]PMID:10086886
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTDQuercetin inhibits the reaction [Calcium Chloride results in increased activity of MMP2 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP2 mRNA]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of MMP2 protein]; resveratrol inhibits the reaction [Calcium Chloride results in increased activity of MMP2 protein]PMID:21530968 PMID:22728078 PMID:24337353
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