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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:18357
Term: (R)-noradrenaline
Definition: The R-enantiomer of noradrenaline.
Chemical ID: MESH:D009638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2increases activityEXP 6480464CTDNorepinephrine results in increased activity of MMP2 proteinPMID:16864425
Mmp2increases expressionEXP 6480464CTDNorepinephrine results in increased expression of MMP2 mRNAPMID:14577597 PMID:15326086 PMID:16864425
Mmp2multiple interactionsEXP 6480464CTDCromolyn Sodium inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; Metoprolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; Norepinephrine results in increased activity of and results in increased expression of MMP2 protein; Prazosin inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased activity of MMP2 protein]; trans-sodium crocetinate inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]PMID:14577597 PMID:15326086 PMID:16864425
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDNorepinephrine results in increased expression of MMP2 mRNAPMID:24929186
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDPropranolol inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]; SB 203580 inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]PMID:24929186
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