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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621295
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mvk
Name: mevalonate kinase
Acc ID: CHEBI:50277
Term: farnesyl diphosphate
Definition: A farnesyl phosphate that has formula C15H28O7P2.
Chemical ID: MESH:C004808
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mvkdecreases activityISOMVK (Homo sapiens)6480464CTDfarnesyl pyrophosphate results in decreased activity of MVK proteinPMID:9392419
Mvkdecreases chemical synthesisISOMVK (Homo sapiens)6480464CTDMVK protein mutant form results in decreased chemical synthesis of farnesyl pyrophosphatePMID:24073415
Mvkmultiple interactionsISOMVK (Homo sapiens)6480464CTDfarnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]PMID:9392419
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