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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621121
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk6
Name: cyclin-dependent kinase 6
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk6decreases activityISOCDK6 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased activity of CDK6 proteinPMID:10850458
Cdk6decreases expressionISOCDK6 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of CDK6 mRNA; Arsenic Trioxide results in decreased expression of CDK6 proteinPMID:10850458 PMID:29266867
Cdk6multiple interactionsISOCDK6 (Homo sapiens)6480464CTD[Arsenic Trioxide results in decreased activity of CDK6 protein] which results in decreased phosphorylation of RB1 protein; [BIBR 1532 co-treated with Arsenic Trioxide] affects the expression of CDK6 mRNA; [Dasatinib co-treated with Arsenic Trioxide] results in decreased expression of CDK6 mRNA; Arsenic Trioxide promotes the reaction [CDK6 protein binds to CDKN1A protein]; Arsenic Trioxide results in decreased expression of and results in decreased activity of CDK6 proteinPMID:10850458 PMID:12480548 PMID:29266867 PMID:32645343
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