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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621121
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk6
Name: cyclin-dependent kinase 6
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk6increases expressionISOCDK6 (Homo sapiens)6480464CTDNicotine results in increased expression of CDK6 mRNAPMID:16949557
Cdk6multiple interactionsISOCDK6 (Homo sapiens)6480464CTDNicotine promotes the reaction [CDK6 protein binds to CCND1 protein]PMID:18805435
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