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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1affects expressionEXP 6480464CTDbisphenol A affects the expression of COL1A1 mRNAPMID:30951980
Col1a1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of COL1A1 mRNAPMID:25594700
Col1a1increases expressionEXP 6480464CTDbisphenol A results in increased expression of COL1A1 mRNA; bisphenol A results in increased expression of COL1A1 proteinPMID:32156529 PMID:32370801 PMID:33221593 PMID:35051763
Col1a1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of COL1A1 mRNA; bisphenol A promotes the reaction [Dietary Fats results in increased expression of COL1A1 mRNA]; ESR2 protein affects the reaction [bisphenol A results in increased expression of COL1A1 protein]PMID:30951980 PMID:33265944 PMID:35051763
Col1a1affects expressionISOCol1a1 (Rattus norvegicus)6480464CTDbisphenol A affects the expression of COL1A1 mRNAPMID:25181051
Col1a1decreases expressionISOCol1a1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of COL1A1 mRNAPMID:30816183 PMID:32145629 PMID:32528016 PMID:34097993 PMID:34884472 PMID:34947998
Col1a1increases expressionISOCol1a1 (Rattus norvegicus)6480464CTDbisphenol A results in increased expression of COL1A1 mRNA; bisphenol A results in increased expression of COL1A1 proteinPMID:27025157 PMID:32145629
Col1a1increases expressionISOCOL1A1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of COL1A1 proteinPMID:34186270
Col1a1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of COL1A1 mRNA]; [bisphenol A co-treated with Dietary Fats] results in increased expression of COL1A1 mRNA; [bisphenol A co-treated with Dietary Fats] results in increased expression of COL1A1 protein; fulvestrant inhibits the reaction [bisphenol A results in increased expression of COL1A1 mRNA]PMID:25112833 PMID:27025157
Col1a1multiple interactionsISOCOL1A1 (Homo sapiens)6480464CTD[[ginger extract results in increased abundance of Oils, Volatile] which co-treated with bisphenol A] affects the expression of COL1A1 proteinPMID:33376534
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