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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of COL1A1 mRNAPMID:15034205 PMID:21569818 PMID:22228805
Col1a1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of COL1A1 mRNAPMID:33429317
Col1a1multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of COL1A1 mRNAPMID:27858113
Col1a1decreases expressionISOCol1a1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of COL1A1 mRNAPMID:21839799
Col1a1decreases expressionISOCOL1A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of COL1A1 mRNAPMID:21632981 PMID:22581694
Col1a1increases expressionISOCOL1A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of COL1A1 mRNAPMID:20106945
Col1a1increases methylationISOCOL1A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of COL1A1 exon; Benzo(a)pyrene results in increased methylation of COL1A1 promoterPMID:27901495
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