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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:132471
Term: (+)-schisandrin B
Definition: An organic heterotetracyclic compound that is found in Fructus Schisandrae and Schisandra chinensis.
Chemical ID: MESH:C015499
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1decreases expressionISOCOL1A1 (Homo sapiens)6480464CTDschizandrin B results in decreased expression of COL1A1 mRNAPMID:31697999
Col1a1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTDschizandrin B inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]PMID:31697999
Col1a1multiple interactionsISOCOL1A1 (Homo sapiens)6480464CTDMIR30E mRNA affects the reaction [schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; MIR30E mRNA affects the reaction [schizandrin B results in decreased expression of COL1A1 mRNA]; schizandrin B inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]PMID:31697999
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