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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621014
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tk1
Name: thymidine kinase 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tk1affects expressionISOTK1 (Homo sapiens)6480464CTDFluorouracil affects the expression of TK1 mRNAPMID:16557594
Tk1affects response to substanceISOTK1 (Homo sapiens)6480464CTDTK1 protein affects the susceptibility to FluorouracilPMID:15548681
Tk1multiple interactionsISOTK1 (Homo sapiens)6480464CTDFluorouracil promotes the reaction [geraniol results in decreased expression of TK1 mRNA]PMID:15374632
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