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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:28854
Term: 2,4-D
Definition: A chlorophenoxyacetic acid that is phenoxyacetic acid in which the ring hydrogens at postions 2 and 4 are substituted by chlorines.
Chemical ID: MESH:D015084
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases expressionEXP 6480464CTD2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP8 protein; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP8 protein modified formPMID:36214342
Casp8multiple interactionsEXP 6480464CTD[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] affects the reaction [Ethanol results in increased expression of CASP8 mRNA]; [2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of CASP8 mRNA; Ethanol affects the reaction [[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of CASP8 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP8 protein modified form]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP8 protein]PMID:36085217 PMID:36214342
Casp8increases expressionISOCasp8 (Mus musculus)6480464CTD2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP8 protein; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP8 protein modified formPMID:36214342
Casp8multiple interactionsISOCasp8 (Mus musculus)6480464CTDFAS protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP8 protein modified form]; FAS protein promotes the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP8 protein]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP8 protein modified form]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CASP8 protein]PMID:36214342
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