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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620925
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:17154
Term: nicotinamide
Definition: A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Chemical ID: MESH:D009536
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1amultiple interactionsEXP 6480464CTD[Niacinamide results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A proteinPMID:23422569
Ppargc1aincreases acetylationISOPPARGC1A (Homo sapiens)6480464CTDNiacinamide results in increased acetylation of PPARGC1A proteinPMID:19071085
Ppargc1amultiple interactionsISOPpargc1a (Mus musculus)6480464CTD[Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [SIRT1 protein results in increased expression of PPARGC1A mRNA]PMID:23891692
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