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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620763
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccn1
Name: cellular communication network factor 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccn1affects response to substanceISOCCN1 (Homo sapiens)6480464CTDCCN1 affects the susceptibility to FluorouracilPMID:15067352
Ccn1increases expressionISOCCN1 (Homo sapiens)6480464CTDFluorouracil results in increased expression of CCN1 mRNA; Fluorouracil results in increased expression of CCN1 proteinPMID:17699798 PMID:24737281
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