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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620760
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plk2
Name: polo-like kinase 2
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plk2increases expressionISOPLK2 (Homo sapiens)6480464CTDFluorouracil results in increased expression of PLK2 mRNAPMID:17982676
Plk2multiple interactionsISOPLK2 (Homo sapiens)6480464CTDTP53 protein affects the reaction [Fluorouracil results in increased expression of PLK2 mRNA]; TP53 protein promotes the reaction [Fluorouracil results in increased expression of PLK2 mRNA]PMID:15016801 PMID:17982676
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