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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620666
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k6
Name: mitogen-activated protein kinase kinase 6
Acc ID: CHEBI:83267
Term: filipin III
Definition: A macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis.
Chemical ID: MESH:D005372
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k6multiple interactionsEXP 6480464CTDFilipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [Iron promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [Iron results in increased phosphorylation of MAP2K6 protein]PMID:17172471
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