GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Map2k6 | affects expression | EXP | | 6480464 | CTD | nickel chloride affects the expression of MAP2K6 mRNA | PMID:22110744 | Map2k6 | increases response to substance | ISO | Map2k6 (Mus musculus) | 6480464 | CTD | MAP2K6 protein results in increased susceptibility to nickel chloride | PMID:21544193 | Map2k6 | multiple interactions | ISO | Map2k6 (Mus musculus) | 6480464 | CTD | [incomplete Freund's adjuvant co-treated with Freund's Adjuvant co-treated with nickel chloride] results in increased expression of MAP2K6 mRNA; [incomplete Freund's adjuvant co-treated with Freund's Adjuvant co-treated with nickel chloride] results in increased phosphorylation of MAP2K6 protein; [MAP2K6 protein results in increased susceptibility to nickel chloride] which results in increased expression of IFNG protein; [MAP2K6 protein results in increased susceptibility to nickel chloride] which results in increased expression of IL10 protein; GADD45A protein inhibits the reaction [nickel chloride results in increased activity of MAP2K6 protein] | PMID:21544193 PMID:23536762 | | ||||||||||||||||||||||
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